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Patel, M. M.
- Designing and Evaluation of Floating Microspheres of Verapamil Hydrochloride: Effect of Methocel
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Authors
Affiliations
1 Arihant School of Pharmacy and BRI, Adalaj-382421, S. G. Highway, Ghandhinagar, Gujarat, IN
2 Kalol Institute of Pharmacy, Kalol, Gujarat, IN
3 Arihant School of Pharmacy and Bioresearch Institute, Ghandhinagar, Gujarat, IN
4 Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa, IN
1 Arihant School of Pharmacy and BRI, Adalaj-382421, S. G. Highway, Ghandhinagar, Gujarat, IN
2 Kalol Institute of Pharmacy, Kalol, Gujarat, IN
3 Arihant School of Pharmacy and Bioresearch Institute, Ghandhinagar, Gujarat, IN
4 Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 1 (2009), Pagination: 22-28Abstract
The floating microspheres have been utilized to obtain prolonged and uniform release in the stomach for development of a once daily formulation. The major advantage of the preparation technique includes short processing time, the lack of exposure of the ingredients to high temperature and high encapsulation efficiencies. The aim of present investigation was to prepare and evaluate gastroretentive floating microspheres of verapamil hydrochloride that would retain the drug in stomach and continuously release the drug in controlled manner. Floating microspheres were prepared by emulsion solvent evaporation technique. In the present investigation three polymers were used in various concentrations; Methocel K4M, Methocel K15M and Methocel K100M. In vitro performance was evaluated by the usual pharmacopoeial and other tests such as particle size analysis, drug entrapment efficiency, flow properties, in vitro floatability studies, in vivo floatability studies in dog, in vitro drug release studies, stability studies etc. Results showed that the mixing ratio of components in the organic phase affected the size distribution, yield, drug content, floating time and drug release of microspheres. In vitro drug release studies were performed for all the prepared formulations. Rank order for percentage cumulative drug release was found to be Methocel K4M > Methocel K15M > Methocel K100M. In most cases good in vitro floating behavior was observed and a variety of drug release pattern could be achieved by variation of the drug, polymer and solvent ratio. The developed floating microspheres of Verapamil hydrochloride may be used for prolonged drug release in stomach for more than 8 h.Keywords
Floating Microspheres, Verapamil Hydrochloride, In Vitro Release, Methocel.
- Assessment of the Knowledge Level of Potato Growers in Madhya Pradesh
Abstract Views :242 |
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Authors
Affiliations
1 Rajmata Vijayaraje Scindia Krishi Vishwavidyalaya, Gwalior (M.P.), IN
2 Krishi Vigyan Kendra, Dewas (M.P.), IN
3 Krishi Vigyan Kendra, Sehore (M.P.), IN
1 Rajmata Vijayaraje Scindia Krishi Vishwavidyalaya, Gwalior (M.P.), IN
2 Krishi Vigyan Kendra, Dewas (M.P.), IN
3 Krishi Vigyan Kendra, Sehore (M.P.), IN
Source
Agriculture Update, Vol 12, No 1 (2017), Pagination: 119-121Abstract
The study was conducted to assess the knowledge level of potato growers in Gwalior district of Madhya Pradesh. The productivity level of potato is observed to be low in Madhya Pradesh due to various reasons among these are climate and adoptability of technologies. Potato production has played a vital role in increasing vegetable production of the country with 25.6 per cent share in total vegetable production during 2002-03. The contribution of the country in world potato pool has increased from 6.4 per cent to 7.8 per cent during last decade. Potato utilization has become more diverse with processed products commanding a large share of the potato market. Majority of the potato growers had complete knowledge about improve varieties. The data also indicated that majority of the potato growers were aware about recommended spacing (59.17%), disease management (56.67%) and selection of field (52.5%).Keywords
Assessment, Knowledge Level, Potato Growers.References
- Choudhary, S. (1995). Training need of tribal farm women. Maharashtra. J. Extn. Edu., 14 : 193- 195.
- Govindagowda, V., Lakshminarayana, M.T. and Chandrashekhar, S.V. (2000). Knowledge and farmers on dryland farming practices in groundnut cultivation. J. Extn. Edu., 11(1): 651-655.
- Jain, Rakesh (2008). A study on entrepreneurship of the vegetable growers of Indore district of Madhya Pradesh. M.Sc. (Ag.) Thesis, Jawaharlal Nehru Krishi Vishwa Vidhyala, Jabalpur, M.P. (INDIA).
- Kubde,V.R., Bhople, S.R. and Tekale, V.S. (2000). Knowledge and adoption of cultivation and storage practices of potato in Ambegaon Panchayat Samit of Pune district. Maharashtra J. Extn. Edu., 19 : 293-297.
- Piparde, S. (2012). A study on training needs of farmers regarding improved potato production technology in Mhow block of Indore district (M.P.). M.Sc. (Ag.) Thesis, Rajmata Vijayaraje Scindia Krishi Vishwavidyalaya, Gwalior, M.P. (INDIA).
- Scott, G.J. and Suarez, V. (2012). The rise of Asia as the centre of global potato production and some implications for industry. Potato J., 39(1): 1-22.
- Improvement on the Carbon Tetrachloride Inducing Hepatotoxicity in Rats using Ipomoea turpethum Root
Abstract Views :501 |
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Authors
Affiliations
1 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, IN
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, IN
3 SAL Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, IN
4 Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, IN
1 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, IN
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, IN
3 SAL Institute of Pharmaceutical Education and Research, Ahmedabad, Gujarat, IN
4 Vice Chancellor of Gujarat Technological University, Ahmedabad, Gujarat, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 9, No 4 (2017), Pagination: 231-234Abstract
Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. Objective of the present work was to evaluate Hepatoprotective potential of Hydro alcoholic extract of Ipomoea turpethum ischolar_main. This in vivo efficacy was reinforced by a significant dose dependent hepatoprotection (at 100 mg/kg and 200mg/kg dose) in CCl4 induced Hepatotoxicity using wistar rats five in each groups. In this study extract of plant (100mg/kg and 200mg/kg, orally) was given for 6 days daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) is given at 6th day after 2 hours from dosing. The Hepatoprotective activity is confirmed by decreasing the activity of serum enzymes, SGOT, SGPT, ALKP, Bilirubin, Cholesterol, while it significantly increased the reduced Protein levels in dose dependant manner. The study was also supported by histopathology of liver sections. The Hepatoprotective activity of the extract is being comparable to standards Silymarin (200mg/kg). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of natural Hepatoprotectives.Keywords
Hepatotoxicity, SGOT, SGPT, CCl4, Ipomoea turpethum.References
- The Wealth of India, a Dictionary of Indian Raw Materials and Industrial Products, C.S.I.R., New Delhi (India). 1952; 3: 195.
- Kirtikar K. R., Basu B. D., Indian medicinal plants, International Book Distributors, Dehradun.1991; 3(3); 1730.
- Vasudesan N. V., In Indian Medicinal Plants, Vol. IV, Orient Longman Ltd, Chennai. 1995: 172.
- Deeaph G., Malti G., Indian Drugs. 1994; 31: 294.
- Ambasta S.P., The Useful Plants of India, Publications and Information directorate, New Delhi CSIR. 1986: 409.
- Nasar E.L.S.M.M., Comparisons of Convolvulus lantus and C.arvensis. Fitoterapia. 1982; 53: 189-191.
- Sahabuddin, Triterpenois from the stem of Operculina turpethum L. J. Biol. Sci.1999; 8: 157-163.
- The Ayuyrvedic Pharmacopoiea, Govt. of India, Ministry of health and family welfare, New Delhi, 1(2): 133.
- Khalid H. J., Anwar H. G., Evaluation of the protective potential of Artemisia maritime extract on acetaminophen and CCl4 induced liver damage. Journal of Ethnopharmacology. 1995; 47: 43-47.
- Porchezhian E., Ansari S.H., HepatoprotectiveactivityofAbutilon indicum on experimental liver damage in rats. Phytomedicine.2005; 12: 62–64.
- Rao K.S., Mishra S.H., Anti-inflammatory and Hepatoprotective activities of fruits of Moringa pterygosperma gaertn. Ind.J.Nat.Prod. 1998; 3: 14.
- Bahar A., Tanveer A., Shah A. K., Hepatoprotective activity of Luffa echinata fruits. Journal of Ethnopharmacology. 2001; 76: 187–189.
- Galighor A.E., Kozloff E.N., Essentials of practical micro technique, second edition, Lea and Febiger, New York1976; 210.
- Fakurazi, S., I. Hairuszah, J.M. Lip and G. Shanthi, The effect of pretreatment of zerumbone on fatty liver following ethanol induced hepatotoxicity. J. Biol. Sci. 2008: 8: 1348-1351
- Hepatoprotective and Anti-Inflammatory Activities of Hydroalcoholic Extract of Bark of Erythrina Indica
Abstract Views :430 |
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Authors
Affiliations
1 Department of Pharmacognosy, Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, IN
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, IN
3 Gujarat Technological University, Ahmedabad, Gujarat, IN
4 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar, Gujarat, IN
1 Department of Pharmacognosy, Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar-382421, Gujarat, IN
2 Troikaa Pharmaceuticals Ltd., Ahmedabad, Gujarat, IN
3 Gujarat Technological University, Ahmedabad, Gujarat, IN
4 Shree Swaminarayan Sanskar Pharmacy College, Zundal, Gandhinagar, Gujarat, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 4 (2017), Pagination: 189-194Abstract
Background: Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver toxicity and inflammation.
Aim: This present work was done to investigate the Hepatoprotective and Anti-inflammatory activities of Hydroalcoholic extract of Bark of Erythrina indica .
Materials and Methods: Drugs like Silymarin, Carbon tetrachloride, Liquid paraffin, carrageenan, Aspirin were used. For Hepatoprotective activity SGOT, SGPT, ALKP, Total cholesterol, Total bilirubin, Albumin, Total protein Estimation kit and for anti-inflammatory activity carrageenan-induced paw oedema method were used.
Result and discussion: The hepatoprotective activity of the Hydroalcoholic extract was assessed in CCl4 induced hepatotoxic Rats. The extract of plant (300mg/kg and 500mg/kg, orally) was given for 6 days, daily and CCl4 (1 ml/kg, 1:1 with liquid paraffin, s.c.) was given at 6th day after dosing of plant extract. Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALKP, Bilirubin, Cholesterol, Total Protein and Albumin were tested in both CCl4 treated and untreated groups. CCl4 has enhanced the SGOT, SGPT, ALKP and Bilirubin in serum, while Total protein and Albumin were decreased. The study was also supported by histopathology of liver sections. Treatment of Hydroalcoholic extract of Bark of Erythrina indica has brought back the altered levels of biochemical markers to near about normal levels in the dose dependent manner. Antiinflammatory activity was done in rats at a dose 300 and 500 mg/kg in carrageenan-induced paw oedema method. Hydroalcoholic extract of Erythrina indica bark significantly reduced the migration of neutrophils and monocytes. Results of in vivo activity lead to the conclusion that the hydroalcoholic extract of Erythrina indica bark showed predominantly significant activity in dose dependent manner, which is comparable to the standard drug Aspirin. The present study reveals that the Hydroalcoholic extract of Bark of Erythrina indica could afford a significant Hepatoprotective and Anti-inflammatory activity.
Keywords
Erythrina indica, CCl4, SGOT, SGPT, ALKP, Aspirin, Carrageenan.References
- Meyer S.A., Kulkarni A.P., hepatotoxicity. In: Hodgson E., Smart R.C., Editors. Introduction to biochemical toxicology. New York: John Wiley and Sons .2001; 487-490.
- Mascolo N., Sharma R., Jain S.C., Capasso F., J Ethnopharmacol. 1994; 22: 211.
- Mossa J.S., Tariq M., Mohsin A., Aqeel A.M., al-Yahya M.A., alSaid M.S., Am J Chin Med.1991; 19: 223.
- Handa. S.S., Sharma. A., Chakraborty. K.K., Natural products and plants as liver protecting drugs; Fitoterapia.. 1989; 57: 307-351.
- Slater T.F., Sawyer B.C., The Stimulatory effect of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver functions in vitro. Inhibitor effects of free radical scavengers and other agents. Biochem J. 1971; 123: 823-828.
- De Pomerai D. I., Pritchard D. J., Clayton R. M., Biochemical and immunological studies of Lentoid formation in cultures of embryonic chick neural retina and day-old chick lens epithelium. Dev Biol. 1977; 60: 416-427.
- Recknagel R.O., Glende E.A., Dolak J.A., Waller R.L., Mechanisms of carbon tetrachloride toxicity. Pharmacol Ther. 1989; 43: 139-154.
- Venkateswaran S., Pari L., Viswanathan P., Menon V.P., Protective effect of herbal formulation against erythromycin estolate- induce hepatotoxicity in rats. J. Ethnopharmacol. 1997; 57: 161-167.
- Latha U., Rajesh M.G., Latha M.S., Hepatoprotective effect of an Ayurvedic medicine, Ind. Drugs. 1999; 36: 470-473.
- Mithra S.K., Seshadri S.J., Venkataranganna M.V., Gopumadhavan S., Venkatesh Udupa U., Sarma D.N.K., Effect of HD-03-a herbal formulation in Galactosamine induced hepatopathy in rats. Indian J. Physiol. Pharmacol. 2000; 44: 8286.
- Dhuley G.P., Naik S.R., Protective effect if Rhinax, herbal formulation against CCL4 induced liver injury and survival in rats. J. Ethnopharmacol. 1997; 56: 159-164.
- Freidman. S.E., Grendell. J.H., McQuaid. K.R., Current diagnosis and treatment in gastroenterology. New York: Lang Medical Books/McGraw-Hill. 2003; 664-679.
- Mukherjee P.K., Quality Control of Herbal Drugs— An Approach to Evaluation of Botanicals. New Delhi: Business Horizons. 2002.
- Maity T.K., Mandal S.C., Mukherjee P.K., Saha K., Saha B.P., Das J., Pal M., Evaluation of Hepatoprotective potential of Cassia tora leaf extract. Nat Prod Sci. 1997; 3: 122–126.
- Mitchell R. N. and R.S. Cotran, In: Robinsons Basic Pathology, 7th Edn., Harcourt (India) Pvt Ltd., New Delhi. 2000; 33.
- Haque R., Mohammad S., Achinto S., Alimuzzaman M.D., Analgesic Activity of Methanolic Extract of the Leaf of Erythrina variegate. J. Pharm. Sci. 2006; 5(1-2): 77-79.
- Ghani A., Medicinal Plants of Bangladesh with chemical constituents and uses. published by Asiatic Society of Bangladesh. 2nd edition, 222-223.
- Kumar G., Banu G.S., Pappa P.V., Sundrarajan M., and Pandian M.R., Hepatoprotective activity of Trainthema portulacastrum L. against paracetamol and thioaacetamide intoxication in albino rats. J.Ethnopharmacol. 2004; 92(1): 37-40.
- Kamat V.S., Chuo F.Y., Kubo I., Nakanishi K.,. Anti-microbial agents from an East-African medicinal plant, Erythrina abyssinica. Heterocycles 1981; 15: 1163–1170.
- Fomum Z.T., Ayafor J.F., Erythrina studies: Part 2. Structures of the novel prenylated antibacterial flavanones, sigmoidins A–C from Erythrina sigmoidea. J. Chem. Soc., Perkin Trans. 1986; 1: 33–37.
- Fomum Z.T., Ayafor J.F., Mbafor J.T., Erythrina studies: Part 1. Novel antibacterial flavanones from Erythrina sigmoidea. Tetrahedron Lett. 1983; 24: 4127– 4130.
- Fomum Z.T., Nkenfack A.E., Wandji J., Erythrina studies: Part 15. Pharmacological screening of three esters isolated from Erythrina plants. Ann. Fac. Sci. Chim. 1988;2:79– 104.
- Wandji J., Fomum Z.T., Tillequin F., Seguin E., Koch M., Erythrina studies: Part 24. Two isoflavones from Erythrina senegalensis. Phytochemistry. 1994; 35: 245– 248.
- Kirtikar K.R., Basu B.D., Indian medicinal plants, International Book Distributors, Dehradun, 2nd Ed. 1991; Vol-1, 781-784.
- Khalid H. J., Anwar H. G., Evaluation of the protective potential of Artemisia maritime extract on acetaminophen and CCl4 induced liver damage. Journal of Ethnopharmacology. 1995; 47: 43-47.
- Bahar A., Tanveer A., Shah A.K.., Hepatoprotective activity of Luffa echinata fruits. Journal of Ethnopharmacology. 2001; 76: 187–189.
- Porchezhian E., Ansari S.H., Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats. Phytomedicine. 2005; 12: 62–64.
- Rao K.S., Mishra S.H., Anti-inflammatory and Hepatoprotective activities of fruits of Moringa pterygosperma Gaertn. Ind. J. Nat. Prod. 1998; 3: 14.
- Rao K.S., Mishra S.H., Anti-inflammatory and Hepatoprotective activities of fruits of Moringa pterygosperma Gaertn. Ind. J. Nat. Prod. 1998; 3: 14.
- Fakurazi S., Hairuszah I., Nanthini U., Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food and Chemical Toxicology. 2008; 46: 2611– 2615.
- Vishnukanta, Rana A.C., Analgesic and Anti-Inflammatory Activity of Hydroalcoholic Extract of Leaves of Plumbago zeylanica. Phcog Mag. 2008; 4.
- Vendruscolo A., Takaki I., Amado L.E.B., Dantas J. A., Amado C.A.B., Suman R. K. N., Anti-inflammatory and antinociceptive activities of Zingiber officinale Roscoe essential oil in experimental animal models. Ind. J. Pharmacol. 2006; 38(1): 58-59.
- Balian S., Ahmad S., Zafar R., Anti-inflammatory activity of leaf and leaf callus of Silybum marianum (L.) Gaertn. In albino rats. Ind. J. Pharmacol. 2006; 38(3): 213-214.
- Sutradhar R.K., Rahman A. K. M. M., Ahmad M.U., Datta B.K., Bachar S.C., Saha A., Anti-inflammatory activity of Sida cordifolia Linn. Ind. J. Pharmacol. 2006; 38(3): 207-208.
- Ahmet C.O., Ufuk M., Hatice O., Nureddin C., Remzi E.,Hanefi O., Anti-inflammatory and Hepatoprotective Activities of Trigonella foenum-graecum L. Pharmacologyonline. 2008; 2: 126-132.
- Ratheesh M., Helen A., Anti-inflammatory activity of Ruta graveolens Linn on carrageenan induced paw edema in wistar male rats. African Journal of Biotechnology. 2007; 6 (10): 1209-1211.